CML Patients in Blast Crisis Have
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چکیده
Chronic myelogenous leukemia (CML) is associated with the Philadelphia (Ph) chromosome. which results from a reciprocal translocation between chromosomes 9 and 22. This activates the abi oncogene by moving it from chromosome 9 and combining it with sequence located on chromosome 22. The new fusion gene. with chromosome 22 sequence at its 5’ end and chromosome 9-abl sequence at its 3’ end. generates a new messenger RNA (mRNA) and protein that are implicated in the pathogenesis of CML. The breakpoint near the c-abl locus on chromosome 9 can occur within a large area. In contrast. the breakpoints on chromosome 22 are concentrated within a 6 kilobase (kb)
منابع مشابه
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تاریخ انتشار 2005